VPS1 — Fusarium graminearum PH-1

Summary

FgVPS1 (FGRAMPH1_01G24141) on chromosome 4 of Fusarium graminearum PH-1 encodes a dynamin-family GTPase with membrane fusion GTPase activity, membrane scission GTPase motor activity, membrane bending activity, microtubule binding, lipid binding, and GTP binding. The gene is associated with mitochondrial inner membrane fusion and fission, peroxisome fission, vacuole organization, vesicle scission, receptor internalization, macroautophagy, regulation of autophagy, actin polymerization, and mitochondrial inheritance and biogenesis. It is linked to abnormal sporulation efficiency, increased sporulation, decreased spore germination rate, decreased cell death rate, increased necrotic cell death, delayed autophagy, increased pexophagy, absent peroxisomal transport and morphology, abnormal vacuolar morphology and distribution, delayed vacuolar transport, decreased intracellular transport, absent fermentative growth, altered cell cycle progression, and abnormal prion inheritance and formation. The product localizes to mitochondrial membranes, peroxisomes, the fungal-type vacuole membrane, microtubules, the Golgi complex, the plasmalemma, and cell division sites.