MON1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G23919 (MON1) in Fusarium graminearum PH-1 on chromosome 4 encodes a protein containing Mon1 and FUZ/MON1/HPS1 longin domains. The gene is associated with vacuole fusion, intracellular protein transport, vacuolar protein sorting, membrane fusion, endocytosis, vesicle transport, and autophagy. It is linked to the MVB membrane and fungal-type vacuole membrane. Associations include abnormal vacuolar morphology, delayed endocytosis and protein transport, decreased pheromone production and shmoo formation, increased ionic stress and UV resistance, absent mitophagy, and altered mitochondrial distribution and genome maintenance. The gene is also associated with zinc sensitivity and decreased utilization of iron sources. Studies of related genes in other species link the MON1 family to reduced virulence and fusarium head blight, as well as calcium sensitivity and phosphate content.