SUC — Fusarium graminearum PH-1

Summary

FgSUC (SUC) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with pyruvate carboxylase, acetyl-CoA carboxylase, biotin carboxylase, urea carboxylase and allophanate hydrolase activities, and contains domains including Pyruv_COase, biotin carboxylation and ATP-grasp. The gene is associated with malonyl-CoA and fatty acid anabolism, gluconeogenesis, the TCA cycle, urea breakdown, hyphal growth, and mitotic nuclear membrane biogenesis. Its product localises to mitochondria, cytoplasm and cytosol. Phenotypic associations include decreased gamma ray and freeze-thaw resistance, increased apoptosis, abnormal cell cycle progression, reduced mitochondrial genome maintenance, and altered survival in stationary phase. Studies of related genes in other species link the family to reduced virulence and unaffected pathogenicity.