CP1 — Fusarium graminearum PH-1

Summary

FgCP1 (CP1) on chromosome 4 of Fusarium graminearum PH-1 encodes a serine carboxypeptidase, belonging to the peptidase S10 family with a propeptide carboxypeptidase Y domain. The gene is associated with proteolysis, vacuolar protein sorting, Golgi-to-vacuole transport, sexual reproduction, secondary metabolism, and methylation. It localizes to the fungal-type vacuole and its lumen. Phenotypic associations include abnormal nuclear fusion during mating, altered cell death (both increased and decreased), abnormal autophagy, decreased ribophagy and mitophagy, absent pexophagy, delayed endocytosis, abnormal Golgi morphology, increased aneuploidy, and altered prion inheritance and lifespan. The gene is also linked to chemical compound accumulation, protein/peptide accumulation, and protein secretion abnormalities. Related genes in other species connect the family to apoplastic effector function.