HAL4 — Fusarium graminearum PH-1

Summary

FgHAL4 (FGRAMPH1_01G23545) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with a protein kinase domain and serine/threonine kinase activity, and is annotated with ATP-binding and phospholipid-binding activity. The gene is associated with septin ring assembly, cell cycle transitions (G1/S and G2/M), filamentous growth regulation, biofilm formation, nitrogen utilization, and apoptotic signaling. It localizes to the septin ring, bud neck, cell tip, nucleolus, mitochondria, and plasma membrane. Phenotypic associations link FgHAL4 to altered endocytosis, protein transport, cell cycle progression, mating response, pheromone sensitivity, chitin deposition, and increased resistance to ionic and osmotic stress. Related genes in other species connect the family to potassium uptake, acid sensitivity, and starvation resistance, with some sequence-similar genes in other Fusarium species linked to virulence and head blight disease.