PEX4 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G23345 (symbol PEX4, also known as UBC16 or FgUBC16) on chromosome 4 of Fusarium graminearum PH-1 encodes a ubiquitin-conjugating enzyme with ubiquitin-protein transferase activity, ssDNA-dependent ATPase activity, proteasome binding, and ssDNA/ATP binding. The product belongs to the Ub_conjugating_enzyme and UBC families. This gene is associated with peroxisome membrane biogenesis, peroxisome organization, and peroxisomal matrix protein import via receptor recycling. It is linked to regulation of the mitotic metaphase/anaphase transition, asexual reproduction, stress-induced protein degradation, the N-end rule pathway, and cellular response to unfolded proteins. Associations include abnormal vegetative growth, decreased filamentous and invasive growth, abnormal sporulation, decreased mating response, increased mutation frequency, and altered chitin deposition. The protein localizes to the peroxisome membrane, cytoplasm, nucleus, and several ubiquitin ligase complexes. Studies of related genes in other species link the family to reduced virulence.