FHL1 — Fusarium graminearum PH-1

Summary

FgFHL1 (FGRAMPH1_01G23417) on chromosome 4 of Fusarium graminearum PH-1 encodes a proteasome subunit beta-type protein with threonine endopeptidase activity, placing it in the proteasome core complex. The gene is associated with proteasomal protein catabolic processes, protein import, detoxification, cell death, and sexual reproduction including mating, syngamy, and chemoattraction. It localizes to the cytoplasm, cytosol, nucleus, and nuclear envelope. Phenotypic associations link FgFHL1 to abnormal cell cycle progression (including G2/M phase delays and M phase arrest), increased mutation frequency, altered UV resistance, abnormal peroxisomal and Golgi morphology, increased pheromone sensitivity and mating response, and defective shmoo formation. Studies of related genes in other species connect the family to proteasome endopeptidase complex function and, more distantly, to turgor pressure and protein content traits.