LEU1 — Fusarium graminearum PH-1

Summary

FgLEU1 (FGRAMPH1_01G22893) on chromosome 4 of Fusarium graminearum PH-1 encodes a 3-isopropylmalate dehydrogenase, an enzyme with NAD and magnesium binding activity that belongs to the isopropylmalate dehydrogenase family. This gene is associated with L-leucine biosynthesis, pigmentation, asexual and sexual reproduction, the glyoxylate cycle, homologous recombination, morphogenesis, and localises to the cytosol. Phenotypic associations include delayed cytokinesis and cell cycle progression, increased aneuploidy and mitotic recombination, decreased invasive and pseudohyphal growth, altered nutrient uptake and small molecule transport, reduced autophagy, and abnormal RNA accumulation and localisation. The gene is also linked to decreased respiratory metabolism, chemical compound excretion, and survival in stationary phase, alongside increased viability and prion formation.