HAT2 — Fusarium graminearum PH-1

Summary

FgHAT2 (FGRAMPH1_01G23213) on chromosome 4 of Fusarium graminearum PH-1 encodes a WD40-repeat protein belonging to the RBAP46/RBAP48/MSI1 family, with H3-H4 histone carrier activity and histone binding. The gene is associated with chromatin organization, CENP-A containing chromatin assembly, regulation of autophagy, macroautophagy, cellular homeostasis, and regulation of DNA-templated transcription. It localizes to the nucleus, cytoplasm, cytosol, kinetochore, centromere complex, and Rpd3S/Clr6-LE complexes. Phenotypic associations include decreased exponential-phase growth, increased sporulation efficiency, abnormal chromosome segregation, cell cycle delays and arrests across multiple phases, increased polyploidy, decreased gamma ray resistance, and abnormal pseudohyphal growth. Related genes in other species link the family to the Rpd3C(L) complex, ORC6, and ASF1.