brr2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G23295 (symbol brr2) on chromosome 4 of Fusarium graminearum PH-1 encodes a DEAD/DEAH-box helicase with RNA helicase activity, RNA binding, ATP hydrolase activity, and ATP binding. The protein contains multiple helicase and nucleic acid-binding domains, including Hel308_SKI2-like and P-loop NTPase domains. This gene is associated with spliceosome conformational changes that release U4 and U1 snRNPs and generate the catalytic conformation, as well as mRNA cis-splicing via the spliceosome. The encoded product localises to the U5 snRNP, U4/U6.U5 tri-snRNP complex, post-mRNA release spliceosomal complex, spliceosome, cytosol, and nucleus. Studies of related genes in other species link the family to RNA processing and DNA repair functions, though these associations are not established for this specific gene.