ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G23145) on chromosome 4 of Fusarium graminearum PH-1 encodes an ABC-type oligopeptide transporter with ATP hydrolase activity and ATP binding, belonging to the type 1 exporter family. The gene is associated with xenobiotic detoxification via transmembrane export across the plasma membrane, oligopeptide export from the mitochondrion, response to antibiotics, sterol anabolism, secretion, membrane transport, and homeostasis. Its product localises to the fungal-type vacuole, mitochondrial inner membrane, and plasma membrane. Phenotypic associations include abnormal colony colour, vacuolar morphology and distribution, altered cell cycle progression, decreased hyperosmotic and oxidative stress resistance, increased aneuploidy, and reduced anaerobic growth and pheromone production. Related genes in other species link the family to multidrug resistance transporters.