RMD1 — Fusarium graminearum PH-1

Summary

FgRMD1 (FGRAMPH1_01G23113) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein containing the RMD1/Sad1-interacting domain and DUF155 family domain. The gene is annotated to mitochondrial gene expression, sexual reproduction, ascospore formation, spore formation, and the meiotic cell cycle, and its product localises to the nuclear membrane, nucleus, and mitochondrial lumen. FgRMD1 is associated with numerous phenotypes including increased nucleus and nucleolus size, decreased endocytosis, pheromone sensitivity, mating response, respiratory growth, and vegetative growth rate, as well as abnormal cell wall and vacuolar morphology, altered stress resistances (decreased ionic, UV, hyperosmotic, and oxidative; increased metal and general stress), increased chronological lifespan, and altered chemical compound accumulation. Studies of related genes in other species link the family to abnormal vegetative growth, colony appearance, decreased sporulation, auxotrophy, and increased heat sensitivity.