BRE1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G23141 (BRE1) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein with a BRE1-like coiled-coil domain and a RING-type zinc finger, and has been annotated with histone H2BK120 ubiquitin ligase activity and ubiquitin ligase activity. The gene is associated with protein ubiquitination, chromatin organization, and response to stress. It is linked to mycotoxin anabolism, filamentous growth in response to starvation or biotic stimulus, hyphal growth, and cellular response to starvation. The encoded protein localizes to the nucleus and the HULC complex. Studies of related genes in other species link the BRE1 family to loss of pathogenicity and oxidative stress response, though these associations are not established for this specific gene.