VAM7 — Fusarium graminearum PH-1

Summary

FgVAM7 (FGRAMPH1_01G22767) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein containing a t-SNARE domain and a PX domain, and is annotated with SNARE and SNARE binding molecular functions as well as phosphoinositide binding. The gene is associated with vacuole fusion, Golgi-to-vacuole transport, vesicle fusion, membrane fusion, endocytosis, autophagy, protein folding, intracellular protein transport, and sexual reproduction. It is linked to fungal-type vacuole and vacuole membrane, late endosome, and SNARE complex localization. Phenotypic associations include abnormal vacuolar morphology, absent budding and filamentous growth, delayed sporulation, increased UV and alkaline pH resistance, decreased endocytosis and nutrient uptake, and abnormal autophagy, mitophagy, and mating response. Related genes in other species link the family to vacuolar morphogenesis, turgor pressure, calcium sensitivity, and loss of pathogenicity.