ILV3C — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G22485 (symbol ILV3C, also known as FgILV3C) on chromosome 4 of Fusarium graminearum PH-1 encodes a dihydroxy-acid dehydratase, an enzyme that contains a 2Fe-2S cluster and binds metal ions. The product belongs to the sugar-degrading dehydratase and IlvD/EDD protein families. This gene is associated with the biosynthesis of branched-chain amino acids, specifically valine, L-isoleucine, and L-leucine, as well as general amino acid anabolism and hyphal growth. The protein localises to the mitochondrial lumen and mitochondria. Related genes in other species link the dihydroxy-acid dehydratase family to reduced virulence and to invasive pulmonary aspergillosis.