ERG-3 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G22691 (ERG-3, ERG24A) on chromosome 4 of Fusarium graminearum PH-1 encodes a sterol reductase with D14-sterol reductase activity and NADP binding, placing it in the ERG24/DHCR-like family. The product localises to the endoplasmic reticulum membrane. The gene is associated with ergosterol biosynthesis, pyrophosphate metabolism, membrane transport, filamentous growth in response to biotic stimulus, and cellular response to xenobiotic stimulus. Phenotypic associations include abnormal plasma membrane morphology, vacuolar transport defects, decreased spore germination, increased cell death, absent mating response, and altered vegetative growth. Studies of related genes in other species link the family to C-14 sterol reductase function and traits such as oxidative stress response and acid sensitivity.