ATG17 — Fusarium graminearum PH-1

Summary

FgATG17 (FGRAMPH1_01G22473) on chromosome 4 of Fusarium graminearum PH-1 encodes a protein containing an ATG17-like domain and is annotated with protein kinase activator activity and bridging binding. The gene is associated with autophagy, including macroautophagy, mitophagy, pexophagy, and autophagy of the mitochondrion, as well as vacuolar transport, protein transport, proteolysis, sexual sporulation, sporulation, and morphogenesis. The encoded protein localises to the phagophore assembly site (PAS) and PAS membrane. Related genes in other species link this family to virulence phenotypes, including loss of pathogenicity, reduced virulence, and hypervirulence, and to localisation in the ULK complex.