ABCA — Fusarium graminearum PH-1

Summary

FgABCA (FGRAMPH1_01G21661) on chromosome 3 of Fusarium graminearum PH-1 encodes an ABC transporter of the PDR/CDR subfamily, possessing ATP hydrolase activity and ATP binding. This gene is associated with extracellular transport, seed germination, zearalenone biosynthetic process, response to toxic substances, toxin anabolism, xenobiotic detoxification by transmembrane export across the plasma membrane, detoxification, hypersensitivity, and DNA repair. The product localizes to the vacuolar membrane, plasma membrane, and membrane. Phenotypic associations include abnormal small molecule transport, decreased vacuolar distribution, increased vacuolar transport, increased sporulation rate, decreased cell death rate, delayed exit from G0, increased fermentative growth, abnormal replicative and chronological lifespan, and abnormal pseudohyphal growth. Studies of related genes in other species link the family to plant height, leaf number, root length, drought tolerance, and reduced virulence.