ZEB1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G22279, designated ZEB1, encodes a FAD-linked oxidoreductase of the berberine bridge enzyme (BBE) family, possessing isomerase activity, FAD binding, and redox activity. This gene is associated with the zearalenone biosynthetic process and patulin anabolism, linking it to mycotoxin production in Fusarium graminearum PH-1 on chromosome 4. The encoded product localizes to the vacuolar lumen, fungal-type vacuole lumen, vacuole, and extracellular space. ZEB1 is also associated with mycotoxin content as a trait. Related genes in other species, such as those encoding FAD-linked oxidoreductases, are linked to secondary metabolism, though these associations are not yet established for this specific gene.