LAC1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G21557 (LAC1) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with cupredoxin and copper-binding domains, with ferroxidase, p-diphenol:oxygen oxidoreductase, and redox activities, and binds copper. The gene is associated with reductive iron assimilation, cellular response to iron ion starvation, arsenate ion transmembrane transport, response to copper, cellular copper ion homeostasis, and sphingolipid anabolism. Its product localises to the high-affinity iron permease complex, the fungal biofilm matrix, and the extracellular region. Studies of related genes in other species link the family to reduced virulence and unaffected pathogenicity, and to associations with Fusarium ear blight and Triticum hosts.