ABCA — Fusarium graminearum PH-1

Summary

FgABCA (FGRAMPH1_01G21579) on chromosome 3 of Fusarium graminearum PH-1 encodes an ABC transporter of the ABCG/PDR family, possessing ATP hydrolase and ATP-binding activities. The gene is associated with xenobiotic detoxification via transmembrane export across the plasma membrane, extracellular transport, toxin anabolism, detoxification, hypersensitivity, DNA repair, and seed germination. Its product localises to the plasma membrane and membrane. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, altered vacuolar distribution and transport, delayed chemical compound accumulation, absent cell fusion, and abnormal pseudohyphal growth, cell cycle progression, and replicative and chronological lifespan. Studies of related genes in other species link the family to multidrug resistance (e.g., CDR1) and, more distantly, to plant traits such as leaf number, plant height, root length, and drought tolerance.