ppoA — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G21327 (symbol ppoA) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with haem peroxidase, dioxygenase, isomerase and monooxygenase activities, including linoleate 8R-lipoxygenase and 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase functions, and belongs to the oxylipin biosynthesis and metabolism family. The gene is associated with oxylipin and prostaglandin biosynthesis, positive regulation of asexual sporulation, negative regulation of sexual sporulation, and response to oxidative stress. It is also linked to fatty acid and carboxylic acid metabolism, hydrogen peroxide catabolism, and sterigmatocystin biosynthesis. Studies of related genes in other species connect the family to altered virulence, including hypervirulence and reduced virulence, as well as to aspergillosis and rice blast disease.