NRPS5 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G20955 (NRPS5) on chromosome 3 of Fusarium graminearum PH-1 encodes a non-ribosomal peptide synthetase, as indicated by its non-ribosomal peptide synthetase activity, ligase activity, phosphopantetheine binding, and isomerase activity. The protein contains domains including an adenylation domain, condensation domain, and phosphopantetheine attachment site. It is associated with amino acid activation for nonribosomal peptide biosynthetic processes, secondary metabolite biosynthesis, and small molecule metabolism, and is localized to the cytoplasm. Studies of related genes in other species link the NRPS5 family to reduced virulence and fusarium head blight in wheat.