FMAG — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G21047 (FMAG, also known as CYP51C) on chromosome 3 of Fusarium graminearum PH-1 encodes a cytochrome P450 family protein with sterol 14-demethylase and methyltransferase activities, iron and heme binding, and redox activity. It is localized to the ER membrane and membrane. The gene is associated with conidium germination, sporulation, demethylation, methylation, and sterol and ergosterol anabolism. Phenotypic associations include decreased micronucleophagy, nucleophagy, ribophagy, and shmoo formation; abnormal cell cycle progression through G2/M and S phases; increased cell death; arrested vegetative and exponential-phase growth; decreased invasive growth, iron and phosphorus utilization, and nutrient uptake; and increased fermentative metabolism and lifespan. Studies of related genes in other species link the CYP51C family to reduced virulence and loss of pathogenicity, as well as to fusarium head blight.