NRPS2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G21053 (NRPS2) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with ligase activity and phosphopantetheine binding. The protein contains condensation, AMP-binding, and phosphopantetheine attachment domains. NRPS2 is associated with ferrichrome, ferricrocin, and siderophore anabolism, nonribosomal peptide anabolism, amino acid activation for nonribosomal peptide biosynthetic process, cellular response to iron ion starvation, cellular iron ion homeostasis, secondary metabolism, siderophore-iron import into cell, and secondary metabolite biosynthesis. The gene product localizes to the cytoplasm. Related genes in other species link the NRPS2 family to increased virulence, unaffected pathogenicity, and reduced virulence, and to associations with fusarium head blight and southern corn leaf blight.