ABC2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G20779 (symbol ABC2, also known as ATM1) in Fusarium graminearum PH-1 on chromosome 3 encodes an ABC transporter with ATP hydrolase activity and ATP-coupled transmembrane transporter activity. The protein localises to the mitochondrial inner membrane and is associated with iron-sulfur cluster export from the mitochondrion, iron-sulfur cluster assembly, cellular iron ion homeostasis, sterol anabolism, secretion, and membrane transport. The gene is linked to numerous phenotypes including abnormal vacuolar morphology, decreased endocytosis, increased pexophagy, altered cell cycle progression, and changes in stress resistance. Related genes in other species are associated with oxidative stress response.