ABCA — Fusarium graminearum PH-1

Summary

FgABCA (FGRAMPH1_01G20839) on chromosome 3 of Fusarium graminearum PH-1 encodes an ABCG-type transporter with ATP hydrolase activity, ATP binding, and identical protein binding, classified as an ABC-type xenobiotic transporter. The gene is associated with azole transmembrane transport, extracellular transport, xenobiotic detoxification via plasma membrane export, cellular response to xenobiotic stimulus, toxin and patulin anabolism, DNA repair, hypersensitivity, cellular monoatomic cation homeostasis, and seed germination. The product localizes to the plasma membrane, vacuolar membrane, and vacuolar lumen. Phenotypic associations include abnormal small molecule transport, decreased vacuolar distribution, increased sporulation rate, altered cell cycle progression, and changes in nutrient uptake, endocytosis, and chronological lifespan. Related genes in other species link the family to multidrug resistance.