YPT1 — Fusarium graminearum PH-1

Summary

FgYPT1 (FGRAMPH1_01G20681) on chromosome 3 of Fusarium graminearum PH-1 encodes a small Rab GTPase with GTPase activity and GTP binding. This gene is associated with a wide range of vesicle-mediated transport processes, including Golgi vesicle fusion, exocytosis, protein secretion, endosome-to-plasma membrane transport, and vacuole organization. It is linked to cell cycle progression, mitotic cytokinesis, and ascospore-type prospore assembly. The encoded protein localizes to the transport vesicle membrane, trans-Golgi network, Spitzenkörper, cleavage furrow leading edge, and growing cell tip. FgYPT1 is associated with altered virulence, abnormal spore germination, delayed vegetative growth, and changes in autophagy, vacuolar transport, and cell cycle progression. Related genes in other species link the family to reduced virulence and responses to oxidative stress and turgor pressure.