ATG8 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G20343 (ATG8) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with an Atg8-like domain and a ubiquitin-like domain, and is associated with phosphatidylethanolamine binding. The gene is linked to autophagy, macroautophagy, mitophagy, lipophagy, regulation of autophagy, cellular response to nitrogen starvation and oxidative stress, protein transport and secretion, deubiquitination, dephosphorylation, NO storage, asexual sporulation, anatomical structure formation involved in morphogenesis, and cellular homeostasis. It localises to the cytoplasm, fungal-type vacuole and its membrane, cytoplasmic vesicle, Cvt vesicle membrane, PAS, and adiposome. Phenotypic associations include delayed autophagy, abnormal filamentous growth, decreased lifespan, arrested mitotic cell cycle, and absent cell cycle progression. Studies of related genes in other species link the family to loss of pathogenicity, reduced virulence, and traits such as biomass yield and germination rate.