MUC1 — Fusarium graminearum PH-1

Summary

FgMUC1 (MUC1, also known as PAC2, PTH2, WOR1) on chromosome 3 of Fusarium graminearum PH-1 encodes a Gti1/Pac2 family protein with sequence-specific DNA binding and transcription factor activity. The gene is associated with the regulation of phenotypic switching, mating, sexual reproduction, conidia formation, hyphal growth, and filamentous growth. It is linked to toxin anabolism, cell adhesion, symbiotic interaction, and biofilm formation on inanimate substrates. The product localizes to the nucleus, chromatin, cytosol, and mitotic spindle pole body. Studies of related genes in other species connect the family to virulence on wheat, maize, rice, and tomato, as well as to altered stress resistance, invasive growth, and vegetative growth.