VPS74 — Fusarium graminearum PH-1

Summary

FgVPS74 (FGRAMPH1_01G20087) on chromosome 3 of Fusarium graminearum PH-1 encodes a GPP34-like domain protein that binds enzymes and phosphatidylinositol-4-phosphate. The gene is associated with Golgi organization, vesicle budding, protein localization to the Golgi apparatus, protein-Golgi retention, vacuolar protein sorting, hyphal growth, and the unfolded protein response. It is linked to protein N-linked glycosylation, O-linked mannosylation, and transport between the Golgi and plasma membrane or rough ER. The product localizes to Golgi cisternae, the trans-Golgi network, Golgi membrane, cytosol, and nucleus. Associations with abnormal Golgi morphology, premature cell cycle transitions, arrested anaphase, decreased lifespan, absent spore germination, and abnormal chitin deposition have been noted. Studies of related genes in other species link the family to reduced virulence.