GGA1 — Fusarium graminearum PH-1

Summary

FgGGA1 (GGA1) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein containing GGA_N-GAT, ARF-binding, GAE, VHS and clathrin-adaptin domains, with molecular functions including phosphatidylinositol-3-phosphate binding, phosphoinositide binding, ubiquitin binding and zinc binding. The gene is associated with trans-Golgi network to endosome transport, Golgi-to-vacuole transport, retrograde endosome-to-Golgi transport, vacuolar protein sorting, and protein vacuolar targeting during ubiquitin-dependent breakdown via the MVB pathway. It localises to the ESCRT-0 complex, trans-Golgi network membrane, endosome membrane, Golgi complex, cytosol and nucleus. Phenotypic associations include abnormal spore germination, filamentous growth, Golgi morphology, endocytosis, micronucleophagy, prion state, cell fusion, meiosis, cell cycle progression, and increased alkaline pH and ionic stress resistance. Studies of related genes in other species link the family to loss of pathogenicity.