afg2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G19771 (symbol afg2) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with an AAA+ ATPase domain, conferring ATP hydrolase, ATP-dependent peptidase, protein disaggregase, protein transporter, and metalloendopeptidase activities, along with polyubiquitin modification-dependent protein binding. The encoded product is associated with mitochondrial and nuclear protein quality control, the INMAD pathway, protein unfolding and dislocation from the ER, ribosome biogenesis and large ribosomal subunit assembly, mitotic spindle breakdown, peroxisome matrix protein import and receptor recycling, SREBP signalling, NO storage, and ubiquitin-dependent proteolysis. It localises to the M-AAA complex, ATPase complex, Vms1-Cdc48-Npl4 complex, Hrd1p ubiquitin ligase complex, RQC complex, p97-Ufd1-Npl4 complex, mitochondrial outer membrane, peroxisome membrane, and nucleolus. Related genes in other species link the family to similar cellular quality control and protein turnover processes.