ARG3 — Fusarium graminearum PH-1

Summary

FgARG3 (FGRAMPH1_01G19935) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein belonging to the Asp/Orn carbamoyltransferase superfamily, with ornithine carbamoyltransferase activity, aspartate carbamoyltransferase activity, carbamoyl-phosphate synthase (ammonia) activity, carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, glutaminase activity, amino acid binding, ATP binding, and metal binding annotated on this gene. The gene is associated with the urea cycle, citrulline anabolism, polyamine metabolism, glutamine metabolism, and de novo UMP biosynthesis and pyrimidine base anabolism. The product localizes to mitochondrial lumen, mitochondria, cytoplasm, cytosol, and nucleus. Phenotypic associations link FgARG3 to decreased cell death rate, abnormal replicative lifespan, abnormal mitochondrial transport, increased freeze-thaw resistance, increased sporulation efficiency, decreased pseudohyphal growth, decreased fermentative growth, absent adhesion, absent nitrogen source utilization, delayed G1/S cell cycle progression, and increased lifespan. Studies of related genes in other species connect the family to abnormal vegetative growth and colony appearance.