CYC8 — Fusarium graminearum PH-1

Summary

FgCYC8 (FGRAMPH1_01G19955) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with enzyme-substrate adaptor activity, chromatin DNA binding, transcription corepressor activity, and RNA polymerase II cis-regulatory region sequence-specific DNA binding. The protein belongs to the Corepressor-Demethylase family and contains TPR repeats. FgCYC8 is associated with negative regulation of transcription by RNA polymerase II, DNA-dependent transcription, and downregulation of transcription. It is linked to appressorium formation, invasive growth, hyphal growth, cell division, cell growth, mitotic metaphase/anaphase transition, anaphase-promoting complex-dependent catabolic processes, protein ubiquitination, chitin anabolism, and glycogen metabolism. The protein localizes to the nucleus, cytoplasm, chromatin, transcription repressor complex, and cyclosome. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.