DUG3 — Fusarium graminearum PH-1

Summary

FgDUG3 (FGRAMPH1_01G19601) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with an EgtC-like domain, a gamma-glutamyl amide hydrolase domain, a GATase_2 domain, and an Ntn hydrolase N-terminal domain. The gene is associated with homologous recombination and signal transduction. Phenotypic associations link FgDUG3 to altered nutrient utilization, including decreased sulfur source utilization and absent nitrogen source utilization, as well as increased UV and oxidative stress resistance, altered heat sensitivity, and changes in replicative and chronological lifespan. The gene is also connected to abnormal colony appearance, altered vegetative growth, and modified competitive fitness. Studies of related genes in other species link the family to glutamine amidotransferase activity.