CPD1 — Fusarium graminearum PH-1

Summary

FgCPD1 (FGRAMPH1_01G19175) on chromosome 3 of Fusarium graminearum PH-1 encodes a tRNA m(1)A(58) methyltransferase, a SAM-dependent methyltransferase with a TRM61_C domain. The gene is associated with tRNA methylation and localises to the cytosol, nucleus and the tRNA (m1A) methyltransferase complex. Phenotypic associations link FgCPD1 to increased anaerobic growth, alkaline pH resistance, osmotic stress resistance, viability, filamentous growth, invasive growth, replicative and chronological lifespan, and oxidative stress resistance, alongside decreased pseudohyphal growth, biofilm formation, acid pH resistance, endocytosis, UV resistance, and acquired and innate thermotolerance. The gene is also associated with delayed G1/S cell cycle progression, abnormal cell cycle progression, decreased nucleolus size, altered RNA and protein accumulation, decreased transposable element transposition, and auxotrophy. Related genes in other species link the family to tRNA methylation.