TPS1 — Fusarium graminearum PH-1

Summary

FgTPS1 (FGRAMPH1_01G19369) on chromosome 3 of Fusarium graminearum PH-1 encodes a trehalose-6-phosphate synthase with trehalose synthase, trehalose-phosphatase and transglucosylase activities, and contains Trehalose_OtsA and Glyco_trans_20 domains. The gene is associated with trehalose and mycose biosynthesis and metabolism, as well as chitin and mycotoxin anabolism, secondary metabolism, the TCA cycle, and carbohydrate metabolism. It is linked to cellular responses to desiccation, heat, hydrogen peroxide and general stress, and to filamentous growth in response to heat and biotic stimuli. Associations with sexual reproduction, ascospore formation, sporulation and lateral growth have been observed. The encoded protein localises to the cytosol, nucleus and trehalose-6-phosphate synthase complex. Related genes in other species link it to sporogenesis, turgor pressure, oxidative stress response, and loss of pathogenicity.