ASPD — Fusarium graminearum PH-1

Summary

FgASPD (FGRAMPH1_01G19335) on chromosome 3 of Fusarium graminearum PH-1 encodes a septin family protein with a G_SEPTIN_dom and P-loop_NTPase domain, possessing GTPase activity, GTP binding, phosphatidylinositol binding, and structural cytoskeletal constituent activity. The gene is associated with septin ring assembly and disassembly, cytokinesis, contractile ring assembly, division septum assembly, chitin localization, ER polarization, hyphal growth, chlamydospore formation, sexual reproduction, and adhesion to host. Phenotypic associations include abnormal cell cycle progression, cytokinesis, budding, filamentous growth, mating efficiency, cell fusion, endocytosis, vacuolar transport, and increased hydrostatic pressure resistance, as well as sterility and altered stationary phase entry. The protein localizes to septin structures including the cleavage apparatus, mitotic and meiotic septin complexes, prospore and mating projection septin rings, and septin filament arrays.