SAS3 — Fusarium graminearum PH-1

Summary

FgSAS3 (FGRAMPH1_01G19361) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with MYST_HAT, HAT_MYST-type, Acyl_CoA_acyltransferase, and WH-like_DNA-bd_sf domains. The gene is associated with multiple enzyme activities, including histone H3K4, H3K14, H4K12 acetyltransferase, peptide butyryltransferase, crotonyltransferase, and 2-hydroxyisobutyryltransferase activities, as well as chromatin binding and transcriptional co-regulation. It is linked to localization in the NuA3a, Piccolo, and TIP60 histone acetyltransferase complexes, centric heterochromatin, and DNA double-strand break sites. FgSAS3 is associated with perithecium formation, spermidine anabolism, positive regulation of triglyceride biosynthesis, heterochromatin boundary formation, DNA repair-dependent chromatin remodeling, and regulation of secondary metabolite biosynthesis. Phenotypic associations include decreased lifespan, absent filamentous growth, decreased adhesion, increased nutrient and carbon source utilization, and abnormal cell cycle progression through G2/M phase. Related genes in other species link the family to histone acetylation and biofilm formation.