PAR1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G19019 (PAR1/RTS1) in Fusarium graminearum PH-1 encodes a protein with protein phosphatase activator activity and protein binding, bridging function, containing a PP2A_B56 domain and ARM-type fold. The gene is associated with meiotic sister chromatid cohesion, mitotic G1 cell size control checkpoint, anaphase cohesion protection, traversing the start control point of the mitotic cell cycle, mitotic spindle assembly deactivation, dephosphorylation, hyphal growth, signal transduction, and cell division. It localizes to the PP2A complex, inner kinetochore, meiotic spindle, centromere complex, mitotic actomyosin contractile ring, mitotic spindle pole body, cell tip, and cell division site. Phenotypic associations include decreased cell cycle progression rate, decreased autophagy and pexophagy rates, increased mating type switching, absent X-ray resistance, decreased hypoosmotic stress resistance, and abnormal sporulation efficiency. Studies of related genes in other species link the family to potassium concentration and oxidative stress response.