ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G18277) on chromosome 3 of Fusarium graminearum PH-1 encodes an ABC transporter of the PDR/CDR/ABCG subfamily, possessing ATP hydrolase activity and ATP binding. The protein localises to the vacuolar membrane and the plasma membrane. Annotated associations link FgABC2 to patulin and sterol biosynthesis, secretion, and homeostasis. Phenotypic evidence connects the gene to absent hyperosmotic and oxidative stress resistance, decreased hypoosmotic stress resistance, and abnormal vacuolar morphology and distribution. Additional associations include increased pexophagy, decreased endocytosis, abnormal cell cycle progression, increased entry into G0, decreased fermentative metabolism, and altered organelle distribution. Related genes in other species link the family to mitochondrial function, though these are not established for FgABC2 itself.