ERG6 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G18649 (ERG6, ERG6B) on chromosome 3 of Fusarium graminearum PH-1 encodes a sterol 24-C-methyltransferase, a member of the Erg6/SMT methyltransferase family. The gene is annotated to sterol 24-C-methyltransferase activity, identical protein binding, ergosterol anabolism, methylation, and pyrophosphate metabolism. Its product localises to the endoplasmic reticulum, mitochondria, nucleus, and adiposome. Associations link ERG6 to numerous cellular and stress-related phenotypes, including abnormal filamentous growth, colony color, plasma membrane and ER morphology, delayed shmoo formation and cell cycle progression, increased adhesion and polyploidy, decreased endocytosis and cell fusion, and absent hyperosmotic stress resistance and anaerobic growth. The gene is also linked to reduced virulence, cell membrane stability, and ion content traits through family-level evidence.