ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G18233) on chromosome 3 of Fusarium graminearum PH-1 encodes an ABC transporter with ATP hydrolase activity, haem-transporting ATPase activity, and cadmium ion transmembrane transporter activity. The protein localises to the fungal-type vacuole membrane, Golgi complex, and plasma membrane. It is associated with cellular detoxification of cadmium ions, haem export from vacuole to cytoplasm, glutathione and phytochelatin transport into vacuole, xenobiotic detoxification, sterol and cichorine biosynthesis, filamentous growth in response to starvation and biotic stimuli, homotypic vacuole fusion, and secretion. Phenotypic associations include altered vacuolar morphology and distribution, increased pexophagy, decreased endocytosis, abnormal cell cycle progression, increased entry into G0 stationary phase, decreased prion inheritance, and altered stress resistance.