ATG1 — Fusarium graminearum PH-1

Summary

FgATG1 (FGRAMPH1_01G18179) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein serine/threonine kinase with ATP-binding activity, belonging to the Atg1-like family. The gene is associated with autophagy regulation, including macroautophagy, mitophagy, pexophagy, ER-phagy, and autophagic cell death. It is linked to conidium germination, positive regulation of conidium formation, sexual sporulation, appressorium formation, and responses to starvation, nitrogen, and potassium ion deprivation. The encoded protein localizes to the phagophore, pre-autophagosomal structure, and vacuole–IM contact sites. Phenotypic associations include abnormal colony size, delayed autophagy, increased necrotic cell death, absent meiosis, decreased cell cycle progression, and altered vacuolar transport. Related genes in other species are linked to virulence, including reduced and increased pathogenicity, as well as nitrogen and sugar content traits.