BYR2 — Fusarium graminearum PH-1

Summary

FgBYR2 (FGRAMPH1_01G18031) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with a Ras-binding domain, SAM domain, and a serine/threonine kinase domain, annotated with MEKK activity and protein serine kinase activity. The gene is associated with multiple MAPK cascades, including the JNK cascade, p38 cascade, cell integrity MAPK cascade, and pheromone response MAPK cascade. It is linked to fungal-type cell wall organization, conidia formation, hyphal growth, sexual reproduction, mating, spore formation, secretion, morphogenesis, and contractile ring assembly. Localization associations include the division septum, cell tip, cell division site, plasmalemma, and cytoplasm. Phenotypic associations include absent mating efficiency, abnormal carbon source utilization, absent osmotic stress resistance, decreased cell cycle progression, and increased polyploidy rate. Studies of related genes in other species link the family to reduced virulence and fusarium head blight.