LAC1 — Fusarium graminearum PH-1

Summary

FgLAC1 (FGRAMPH1_01G18127) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with a Lag1/Lac1-like domain and TLC domain, localised to the ER membrane. The gene is associated with ceramide synthase activity, ceramide and sphingolipid biosynthesis, hyphal growth, and the meiotic cell cycle. It has been linked to numerous phenotypes including altered endocytosis, decreased chitin deposition, abnormal budding, increased alkaline pH resistance, decreased apoptosis, increased hyperosmotic stress resistance, and altered stationary phase survival and entry into G0. The gene is also associated with DGT1, FUM17, FUM18, and ALT7 proteins. Related genes in other species connect this gene to sphingosine N-acyltransferase activity (EC 2.3.1.24) and ceramide synthase function, though these relationships are not yet established in F. graminearum.