CAG1 — Fusarium graminearum PH-1

Summary

FgCAG1 (FGRAMPH1_01G18151) on chromosome 3 of Fusarium graminearum PH-1 encodes a guanine nucleotide-binding protein alpha subunit, a member of the fungal G-protein alpha family with GTPase activity and GTP binding capacity. The gene is associated with heterotrimeric G-protein complex localization at the mitochondrial outer membrane and cytoplasm. It is linked to sexual reproduction processes including perithecium development and formation, sporocarp development, and karyogamy. FgCAG1 is associated with regulation of conidium formation, mycotoxin and sterigmatocystin biosynthesis, and penicillin anabolism. Phenotypic associations include abnormal mating response and efficiency, altered pheromone sensitivity and production, delayed sporulation, and increased polyploidy rate. Related genes in other species are linked to loss of pathogenicity and reduced virulence.