HSP98 — Fusarium graminearum PH-1

Summary

FgHSP98 (HSP98) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with ClpR_N, Clp_N_dom_sf, ClpA/ClpB_AAA_lid, ClpA/B_CS1, ClpA/B_CS2, ClpA_ClpB, Clp_ATPase_C, ClpA/B, ATPase_AAA_core, AAA+_ATPase, and P-loop_NTPase domains, and is annotated with ATP-dependent protein disaggregase activity, misfolded protein binding, chaperone protein binding, and ATP hydrolase activity. It is associated with cellular response to misfolded protein, cellular thermotolerance, protein stabilization, protein unfolding, protein refolding, dephosphorylation, cellular response to heat, protein breakdown, and autophagy. The gene is linked to abnormal nitrogen source utilization, absent fermentative metabolism, altered prion inheritance, and abnormal chemical compound excretion. Related genes in other species connect the family to reduced virulence and oxidative stress response.