SIB2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G17749 (symbol SIB2, also known as SID1) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein with ornithine N5-monooxygenase activity, a member of the Lys/Orn_oxygenase and FAD/NAD-binding superfamilies. The enzyme also exhibits N,N-dimethylaniline monooxygenase activity, NADP+ and iron binding, and monooxygenase activity. This gene is associated with ferrichrome and siderophore biosynthesis, siderophore-iron import, cellular iron ion homeostasis, and the response to iron ion starvation. It is also linked to ergosterol biosynthesis, secretion, secondary metabolite production, and the cellular response to oxidative stress. Studies of related genes in other species connect the family to reduced virulence and loss of pathogenicity, as well as to fusarium ear blight.